Confocal image of sciatic nerve from adult mouse from a paper by Weng et al. Immunofluorescence staining of myelin incisures by the adherens junction component, alpha-T-catenin (magenta). F-actin is stained by Phalloidin (cyan). Maximum z-projection of 65 steps (0.5 microns/step). Distance between immunostained incisure ‘bands’ is ~30-50 microns. Image licensed under a Creative Commons Attribution 4.0 International license.
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Latest trends in bioimaging and building a proactive network of early-career young scientists around bioimaging in Europe
Summary: This Meeting Review highlights the latest trends in bioimaging discussed at the Third Imabio YSN Conference 2022 in Lyon which was organized by and dedicated to early-career young scientists.
Actin cytoskeleton in angiogenesis
Summary: Endothelial actin structures and actin-mediated force generation coordinate the multi-step angiogenic process.
The prospect of genetically engineering natural killer cells for cancer immunotherapy
Summary: We review recent progress in natural killer (NK) cells for cancer immunotherapy, from the basics of NK cell biology to chimeric antigen receptor-transduced NK cell applications.
Sevoflurane-induced amnesia is associated with inhibition of hippocampal cell ensemble activity after learning
Summary: This research shows the effect of sevoflurane anesthesia just after learning on amnesia and that sevoflurane inhibits neuronal ensemble activity in hippocampal CA1.
shox2 is required for vestibular statoacoustic neuron development
Summary: Mutant shox2 fish display behaviors associated with vestibular deficits, show reduced number of anterior statoacoustic ganglion neurons that innervate the utricle and have altered otic cell populations defined by single cell RNA-seq.
A genome-wide CRISPR screen implicates plasma membrane asymmetry in exogenous C6-ceramide toxicity
Summary: A genome-wide CRISPR screen reveals a role for TMEM30A-regulated membrane asymmetry in governing cancer cell sensitivity to ceramide-induced cell death.
Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions
Summary: This study assigns alpha-T-catenin to a new tissue and cell-type with implications for its growing disease linkages.
Development of an adenosquamous carcinoma histopathology – selective lung metastasis model
Summary: In vivo modelling of tumor cell lung colonization reveals NSCLC histopathology-selective metastatic capabilities.
Reevaluating the relationship between EGL-43 (EVI1) and LIN-12 (Notch) during C. elegans anchor cell invasion
Summary: Using a dual depletion approach, i.e., combining auxin-inducible degradation with RNAi, we show that LIN-12 is not required for proliferation of the C. elegans anchor cell following EGL-43 loss.
Zebrafish embryos hatch early in response to chemical and mechanical indicators of predation risk, resulting in underdeveloped swimming ability of hatchling larvae
Summary: Zebrafish embryos can hatch early if they sense chemical or mechanical indicators of predation risk, but when they hatch early they are poorly developed and more vulnerable to predators as larvae.
The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut
Summary: ECM remodelling plays a role in the maintenance of intestinal stem cells and crypt morphology during development and in the adult mouse gut.
METHODS & TECHNIQUES
A new software tool for computer assisted in vivo high-content analysis of transplanted fluorescent cells in intact zebrafish larvae
Summary: We present a software tool for automatic cell segmentation of fluorescent cancer cells in zebrafish larvae to determine characteristics of the cancer cell population on a single-cell basis
A Year at the Forefront of...
BiO’s new ‘A Year at the Forefront of…’ series of Review articles by early-career reseearchers aims to highlight key developments that have made an impact in a specific biological field during the past year. Read more and propose a Review here.
Propose a new Workshop for 2025
Application deadline: 30 June 2023 Do you have an idea for a Workshop? We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
Resources for early-career researchers
BiO and our publisher The Company of Biologists offer a number of practical ways to help you meet the unique needs and challenges you may encounter as an early-career researcher (ECR). Visit our dedicated ECR webpage to find out more.
Have a paper that has been reviewed elsewhere? BiO is pleased to consider such manuscripts for fast-tracked decision making. Send us your manuscript together with the full set of reviews and decision letters, and we will make an initial decision in one week (or less).
Future Leader Reviews
BiO’s Future Leader Reviews help early-career researchers:
- Establish themselves in their field
- Find a foothold in a new area after a subject change post-PhD/postdoc
- Build their profile for grant, fellowship and job applications