Yildirim et. al. show the Rumpel SLC5A transporter localizes at the plasma membrane of the ensheathing glia in the Drosophila CNS. The image shows an adult fly brain stained for Repo to define glial nuclei (magenta), N-Cadherin to visualize axonal and dendritic cell membranes (blue) and for Rumpel (green). Rumpel localizes around the neuropil in adult brains at a position of the ensheathing glia. Image licensed under a Creative Commons Attribution 4.0 International license.
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The matrix in focus: new directions in extracellular matrix research from the 2021 ASMB hybrid meeting
Summary: We describe recent advances and new directions in extracellular matrix research presented at the 2021 hybrid scientific meeting organized by the American Society for Matrix Biology.
Developmental disorders caused by haploinsufficiency of transcriptional regulators: a perspective based on cell fate determination
Summary: This Review proposes the hypothesis that developmental disorders caused by haploinsufficiency of transcriptional regulators result from disrupted bistability (i.e. disrupted positive feedback or cooperativity) in the gene-regulatory network of the underlying cell fate decision.
Serotonin: an overlooked regulator of endocytosis and endosomal sorting?
Summary: Serotonin is a neurotransmitter associated usually with our mood, yet recent evidence indicates that serotonin regulates the cell uptake process, endocytosis, diversifying the potential roles of serotonin throughout the body.
Potentiating Vγ9Vδ2 T cell proliferation and assessing their cytotoxicity towards adherent cancer cells at the single cell level
Summary: HMBPP potentiated Vγ9Vδ2 T cell cytotoxicity towards colon cancer cells, assessed at the single cell level using a novel flow cytometric method. Dimethylallyl monophosphate is a phosphoantigen and freshly thawed serum supplementation improves proliferation.
Soluble receptor for advanced glycation end products protects from ischemia- and reperfusion-induced acute kidney injury
Summary: Soluble (s) RAGE reduced tubular injury in mice acute kidney injury (AKI) model. sRAGE attenuated hypoxia induced damage and accelerated proliferation in tubular epithelial cells. sRAGE may be a potential therapeutic option for AKI.
Effects of mechanical stimulation on metabolomic profiles of SW1353 chondrocytes: shear and compression
Summary: SW1353 chondrocyte-like cells respond to shear and compressive stimulation through changes in diverse metabolic pathways between 15 and 30 minutes of stimulation.
Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia
Summary: Here we investigate expression of two apolipoprotein genes by microglia in the zebrafish model during normal development, and in contexts of pharmacological manipulations that target candidate regulatory receptors.
Redundant functions of the SLC5A transporters Rumpel, Bumpel, and Kumpel in ensheathing glial cells
Summary: The Drosophila genes rumpel, bumpel and kumpel, that encode SLC5A proteins expressed in overlapping sets of CNS glial cells act in partially redundant manner during locomotor control and oogenesis.
METHODS & TECHNIQUES
A human stem cell resource to decipher the biochemical and cellular basis of neurodevelopmental defects in Lowe syndrome
Summary: A human iPSC resource to study the cellular basis of neurodevelopmental defects in Lowe syndrome.
Myotonic dystrophy type 1 embryonic stem cells show decreased myogenic potential, increased CpG methylation at the DMPK locus and RNA mis-splicing
Summary: Early developmental abnormalities in myotonic dystrophy type 1 are reiterated in vitro in myotubes differentiated from human embryonic stem cells that carry the mutation.
The Forest of Biologists
The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Biology Open a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.
Propose a new Workshop for 2025
We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
A Year at the Forefront Review
This A Year at the Forefront Review sheds light on the most recent developments in the study of bacterial response to and defence against reactive oxygen and chlorine species. Visit our online Open Access Journal to read all about Sadia Sultana and Jan-Ulrik Dahl's work.
Meeting Review - 14th NYRA Meeting
The 14th NYRA meeting covered a wide range of topics related to male germline research, including the impact of mutations in the male germline on future generations, the use of innovative sequencing tools for the study of male infertility, and the intricate germline epigenome.
Future Leader Reviews
BiO’s Future Leader Reviews help early-career researchers:
- Establish themselves in their field
- Find a foothold in a new area after a subject change post-PhD/postdoc
- Build their profile for grant, fellowship and job applications