Three-dimensional images of basal stem cells on the dorsal trachea from a paper by Tomomi Tadokoro and colleagues. Four different fluorescent proteins (membrane CFP, nuclear GFP, RFP, and YFP) were expressed in tracheal basal stem cells at 1 week after recombination of Krt5-CreER; Rosa-Confetti mice. Z-stack images taken by confocal microscope were reconstructed by Imaris imaging software. Image licensed under a Creative Commons Attribution 4.0 International license.
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Connecting different heart diseases through intercellular communication
Summary: A finely tuned interplay between distinct intercellular communication mechanisms is required for both homeostasis and remodeling of the diseased heart, posing as relevant target to improve the development of therapeutic strategies.
Fracture biomechanics influence local and systemic immune responses in a murine fracture-related infection model
Summary: Physical movement between bone fragments after a fracture influence healing, and are shown here, for the first time, to influence immune responses and infection.
Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway
Summary: The maldevelopment of sensory neurons in Elongator knockout embryos is associated with elevated H2A.Z and perturbed Notch signaling that can be rescued by Trichostatin A.
Rhoptry kinase protein 39 (ROP39) is a novel factor that recruits host mitochondria to the parasitophorous vacuole of Toxoplasma gondii
Summary: We revealed that ROP39 recruitments host mitochondria, possibly through its kinase activity. Exploiting components involved with recruitment of host mitochondria advances the understanding of how the parasites employ mitochondrial recruitment to survive in host cells.
ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane
Summary: This paper investigates the role of ARL13B in targeting of INPP5E to the ciliary membrane, and shows the direct role of ARL13B within cilia, independently of its ARL3-GEF activity.
BMP-treated human embryonic stem cells transcriptionally resemble amnion cells in the monkey embryo
Summary: We show that BMP-treated human embryonic stem cells (hESCs) are more likely to represent an amnion rather than a trophectoderm cell type.
Dorso-ventral heterogeneity in tracheal basal stem cells
Summary: Spatial difference of tracheal epithelium, especially focused on the heterogeneity of basal stem cells, is elucidated by lineage tracing in vivo, histological analysis, tracheosphere culture, and gene ontology analysis.
Insights into in vivo adipocyte differentiation through cell-specific labeling in zebrafish
Summary: Analysis of the differentiation of adipocytes in vivo through cell-specific labeling in zebrafish, revealed their early interaction with blood vessels as well as early lipid metabolic changes.
Transduction of rat and human adipose-tissue derived mesenchymal stromal cells by adeno-associated viral vector serotype DJ
Summary: Adeno-associated viral vectors are widely used for gene delivery but their impact on the different cell types varies greatly and is not well understood. We describe effects of two most popular AAV serotypes on mesenchymal stromal cells of rat and human origin.
Visual acuity of budgerigars for moving targets
Summary: Movement does not improve detection: The detection threshold of budgerigars (Melopsittacus undulatus) for moving dark circular targets is similar to the detection threshold for stationary but otherwise similar targets.
Arf GTPase-activating proteins SMAP1 and AGFG2 regulate the size of Weibel-Palade bodies and exocytosis of von Willebrand factor
Summary: The Arf GTPase-activating proteins SMAP1 and AGFG2 regulate the size of Weibel-Palade bodies and exocytosis of von Willebrand factor.
METHODS & TECHNIQUES
Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice
Summary: This paper provides a comprehensive characterisation of the short-term effects of administration of adeno-associated virus 8 on murine physiology, liver histology and liver transcriptome.
Pigment pattern morphospace of Danio fishes: evolutionary diversification and mutational effects
Summary: A multidimensional morphospace for pigment patterns yields quantitative insights into the evolution and genetics of diverse pigment patterns across zebrafish and related species.
A versatile, automated and high-throughput drug screening platform for zebrafish embryos
Summary: We developed and validated a fast, flexible and rapidly customisable platform, automating both image acquisition and quantitative analysis, for high-content drug screening in live zebrafish embryos.
The Forest of Biologists
The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Biology Open a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.
Propose a new Workshop for 2025
Do you have an idea for a Workshop? We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
A Year at the Forefront Review
This A Year at the Forefront Review sheds light on the most recent developments in the study of bacterial response to and defence against reactive oxygen and chlorine species. Visit our online Open Access Journal to read all about Sadia Sultana and Jan-Ulrik Dahl's work.
The 14th NYRA meeting covered a wide range of topics related to male germline research, topics related to male germline research, including the impact of mutations in the male germline on future generations, the use of innovative sequencing tools for the study of male infertility, and the intricate germline epigenome.
Future Leader Reviews
BiO’s Future Leader Reviews help early-career researchers:
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